生态基因组学及适应性研究组

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飞蝗基因组数据库

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研究组介绍

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生态基因组学及适应性研究组始建于1995年，曾经以蝗虫和斑潜蝇为研究对象，在蝗虫型变、抗寒性和三级营养水平相互作用等方面取得过突出成绩。近年来，该研究组将分子生物学与生态学结合，系统研究了生态基因组、表型可塑性和行为调节机制，为阐明生物对环境变化的响应和适应性做出重要的贡献。他们首次发现嗅觉感受蛋白基因和多巴胺代谢途径对飞蝗型变的启动和维持机制，以及型变的表观遗传规律。这些研究极大地拓展了现代昆虫学的研究领域。该研究组破译了迄今为止最大的昆虫基因组:飞蝗基因组，使飞蝗发展成研究整合生物学和疾病研究的模型成为可能。现在研究组正在研究表型可塑性的表观遗传机制，在响应同种或异种生物信息化合物的过程中揭示了神经系统和行为的交互作用。同时，利用基因组编辑技术发展一系列的突变体模型，为农业和医学需求服务。

研究方向

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1、生态基因组学：在基因组、转录组以及表观遗传水平系统研究昆虫对环境的适应性。

2、表型可塑性研究：研究蝗虫多型、生态免疫、繁殖、衰老和行为的可塑性，为建立相关疾病模型奠定基础。

3、神经生物学及行为：研究神经系统和行为对种内和种间信息化合物的识别、响应机制。

近期论文

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Guo, X.J.^①, Yu, Q.Q.^①, Chen, D.F.^①, Wei, J.N.^①, Yang, P.C., Yu, J., Wang*, X.H., Kang*, L. 2020. 4-Vinylanisole is an aggregation phenomone in locusts. Nature , 584:584-588.

Guo, X.J.,^①, Gao, L.^①, Li, S.W.^① , Gao, J., Wang, Y.Y., Lv, J., Wei, J.Y., Yang, J., Ke, H., Ding, Q., Yang, J., Guo, F.S., Zhang, H.W., Lei*, X.G. and Kang*, L. 2025. Decoding 4-vinylanisole biosynthesis and pivotal enzymes in locusts. Nature, Accepted.

Chang, H.T., Cassau, S., Krieger, J., Guo, X.J., Knaden, M., Kang*, L., Hansson*, B., 2023. A chemical defense deters cannibalism in migratory locusts. Science 380, 537–543.

Guo, X.J., Kang*, L. 2025. Phenotypic Plasticity in Locusts: Trade-off between Migration and Breeding. Annual Review of Entomology, 70:23-44

Li, J., Li, J.J., Cao, L.L., Chen, Q.H., Ding*, D., and Kang*, L. 2024. An iron-binding protein of entomopathogenic fungus suppresses theproliferation of host symbiotic bacteria. Microbiome，12:202

Zhu, Y.N.^①, He, J. ^①, Wang, J.W., Guo, W., Liu, H.R., Song, Z.R., Kang*, L. 2024. Parental experiences orchestrate locust egg hatching synchrony by regulating nuclear export of precursor miRNA. Nature Communication, 15, 4328

Yang, J., Yu, Q.Q., Yu, J., Kang*, L., and Guo*, X.J. 2023. 4-Vinylanisole promotes conspecific interaction and acquisition of gregarious behavior in the migratory locust. PNAS, 120, e2306659120.

Liu, Q.^①, Cui, F.^①, Liu, X., Fu, Y.M., Guo, W., Xia*, Q.F., Kang*, L., and Jiang*, F. 2023. Association of virome dynamics with mosquito species and environmental factors. Microbiome, 11:101

Kang, X.L.^①, Yang, M.L.^①, Cui, X.S., Wang, H.M., and Kang*, L. 2023. Spatially differential regulation of ATF2 phosphorylation contributes to warning coloration of gregarious locusts. Science Advances, DOI: 10.1126/sciadv.adi5168

Wang, H.M. ^①, Jiang, F. ^①, Liu, X. ^①, Liu, Q., Fu, Y.Y., Li, R., Hou, L., Zhang, J., He, J., Kang*, L. 2022. Piwi/piRNAs control food intake by promoting neuropeptide F expression in locusts. EMBO Reports, 5: e50851.

Wang, Y.D., Tong, X.W., Yuan, S.L., Yang, P.C., Li, L., Zhao, Y., Kang*, L. 2022, Variation of TNF modulates cellular immunity of gregarious and solitary locusts against fungal pathogen Metarhizium anisopliae. PNAS, DOI:10.1073/pnas.2120835119.

Du, B.Z.^①, Ding, D.^①, Ma, C., Guo*, W., Kang*, L. 2022. Locust density shapes energy metabolism and oxidative stress resulting in divergence of flight traits. PNAS. DOI: 10.1073/pnas.2115753118.

Wei, J.N., Shao, W.B., Cao, M.M., Ge, J., Yang, P.C., Chen, L., Wang, X.H., Kang*, L. 2019. Phenylacetonitrile in locusts facilitates an antipredator defense by acting as an olfactory aposematic signal and cyanide precursor. Science Advances , DOI 10.1126/sciadv.aav5495.

Guo, X.J., Ma, Z.Y., Du, B.Z., Li, T., Li, W.D., Xu, L.L., He, J., and Kang*, L. 2018. Dop1 enhances conspecific olfactory attraction by inhibiting miR-9a maturation in locusts. Nature Communications , 9(1): 1193.

Ding, D., Liu, G.J., Hou, L., Gui, W.Y., Chen*, B., and Kang*, L. 2018. Genetic variation in PTPN1 contributes to metabolic adaptation to high-altitude hypoxia in Tibetan migratory locusts. Nature Communications . 9(1)：p.4991.

Chen B., Zhang B., Xu L.L., Li Q., Jiang F., Yang P.C., Xu Y.N., Kang L., 2017. Transposable Element-Mediated Balancing Selection at Hsp90 Underlies Embryo Developmental Variation. Molecular Biology and Evolution . doi:10.1093/molbev/msx062

He, J. ^①, Chen, Q.Q. ^①, Wei, Y.Y. ^①, Jiang, F., Yang, M.L., Hao, S.G., Guo, X.J., Chen, D.F., Kang, L. 2016. MicroRNA-276 promotes egg hat ching synchrony by upregulating brm in locusts. PNAS , 113:584-589.

Wang,X.H., Kang,L. 2014.Molecular mechanisms of phase change in locusts. Annual Review of Entomology , 59:225-43.

Wang, X.H. ^①, Fang, X.D. ^①, Yang, P.C. ^①, Jiang, X.T. ^①, Jiang, F. ^①, Zhao, D.J., Li B., Cui, F., Wei, J.N., Ma, C., Wang, Y.D., He, J., Luo Y., Wang, Z.F., Guo, X.J., Guo W., Wang X., Zhang Y., Yang M.L., Hao S.G., Chen B., Ma Z.Y., Yu D., Xiong Z., Zhu Y., Fan D., Han L., Wang B., Chen Y., Wang J., Yang L., Zhao W., Feng Y., Chen G., Lian J., Li Q., Huang Z., Yao X., Lv N., Zhang G., Li Y., Wang J., Wang, J., Zhu B. Kang, L., 2014. Locust genome sequence provides insight into swarm formation and long-distance flight. Nature Communications , 10.1038/ncomms3957.

Cease, AJ, Elser, JJ, Ford, CF, Hao, S., Kang, L, Harrison*, JF. 2012. Heavy livestock grazing promotes locust outbreaks by lowering plant nitrogen content. Science , 335, 467-469.

Wu, R., Wu, Z.M., Wang, X.H., Yang, P.C., Yu, D., Zhao, C.X., Xu, G.W., and Kang, L. 2012. Metabolomic analysis reveals that carnitines are key regulatory metabolites in phase transition of the locusts. PNAS , 109, 3259-3263.

Ma, ZY, Guo, XJ, Guo, W, Wang, XH, Kang, L. 2011. Modulation of behavioral phase changes of the migratory locust by the catecholamine metabolic pathway. PNAS , 108: 3882-3887.

Kang, L., Chen, B., Wei, J.N. and Liu, T.X., 2009. Roles of Thermal Adaptation and Chemical Ecology in Liriomyza Distribution and Control. Annual Review of Entomology , 54:127-145.

Wei, Y.Y., Chen, S., Yang P.C., Kang, L., 2009. Characterization and transcriptomes of small RNAs in two phases of locust. Genome Biology , 10:R6l (doi:10.1186/gb-2009-10-1-r6).

Kang, L., Chen, X.Y., Zhou, Y., Zheng, W., Li R.Q., Wang, J. and Yu, J. 2004. The analysis of large-scale gene expression correlated to the phase changes of the migratory locust.PNAS , 101: 17611-17615.

研究组成员


组长：康乐	组员：郭伟	组员：于丹	组员：郭晓娇	组员：何静	组员：丁玎