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多肽画廊
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朱顺义博士,2001年4月毕业于武汉大学生物技术系,获理学博士学位。同年到比利时鲁汶大学毒素学实验室从事博士后研究。2004年回国工作。现为中国科学院动物研究所二级研究员、博士生导师、研究组长。曾获湖北省自然科学一等奖,享受国务院政府特殊津贴。国家自然科学基金委优秀青年基金项目以及重点项目、国家重点基础研究发展计划(973项目)初审和复审以及中国科学院人才项目评审专家。国家自然科学基金重点项目,重大研究计划项目以及面上项目主持人。国家基金委创新团队项目和国家973项目课题负责人。 ...
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多肽画廊
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发表论文
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Gao B, Zhu S
*
(2024) The evolutionary novelty of insect defensins: from bacterial killing to toxin neutralization.
Cell Mol Life Sci
81:230.
Gao B, Li P, Zhu S
*
(2024) Single deletion unmasks hidden anti-Gram-negative bacterial activity of an insect defensin-derived peptide.
J Med Chem
67:2512–2528.
Gao B, Zhu S
*
(2023) Enhancement of SARS-CoV-2 receptor-binding domain activity by two microbial defensins.
Front Microbiol
14:1195156.
Gao B, Zhu S
*
(2023) Mutation-driven parallel evolution in emergence of ACE2-utilizing sarbecoviruses.
Front Microbiol
14:1118025.
Gu J, Isozumi N, Gao B, Ohki S, Zhu S
*
(2022) Mutation-driven evolution of antibacterial function in an ancestral antifungal scaffold: Significance for peptide engineering.
Front Microbiol
13:1053078.
Qi S, Gao B, Zhu S* (2022) A Fungal Defensin Inhibiting Bacterial Cell-Wall Biosynthesis with Non-Hemolysis and Serum Stability.
J Fungi
8:174.
Zhu S*, Gao B, Umetsu Y, Peigneur S, Li P, Ohki S, Tytgat J (2022) Adaptively evolved human oral actinomyces-sourced defensins showtherapeutic potential.
EMBO Mol Med
14:e14499.
Gu J, Isozumi N, Yuan S, Jin L, Gao B, Ohki S, Zhu S* (2021) Evolution-based protein engineering for antifungal peptide improvement.
Mol Biol Evol
38: 5175–5189.
Gao B, Zhu S* (2021) A fungal defensin targets the SARS-CoV-2 spike receptor-binding domain.
J Fungi
7:553.
Qi S, Gao B, Zhu S* 2021) Molecular diversity and evolution of antimicrobial peptides in
Musca domestica
.
Diversity
13:107.
Zhu L, Gao Bζ, Yuan Sζ, Zhu S* (2019) Scorpion toxins: positive selection at a distal site modulates functional evolution at a bioactive site.
Mol Biol Evol
36: 365-375. (ζ These authors contributed equally to this work)
Zhou W, Gao B, Zhu S* (2018) Did cis- and trans-defensins derive from a common ancestor?
Immunogenetics
71: 61-69.
Ji X, Zhang S, Gao B, Zhu S* (2018) Receptor variability-driven evolution of snake toxins.
Zool Res
39: 431-436.
Zhao Jζ, Yuan Sζ, Gao B, Zhu S* (2018) Molecular diversity of fungal inhibitor cystine knot peptides evolved by domain repeat and fusion.
FEMS Microbiol Lett
365(15). (ζ These authors contributed equally to this work)
Gu J, Gao B, Zhu S* (2018) Characterization of bi-domain drosomycin-type antifungal peptides in nematodes: An example of convergent evolution.
Dev Comp Immunol
87: 90-97.
Gao B, Dalziel J, Tanzi S and Zhu S* (2018) Meucin-49, a multifunctional scorpion venom peptide with bactericidal synergy with neurotoxins.
Amino Acids
50:1025-1043.
Zhang S, Gao B, Wang X and Zhu S* (2018) Loop Replacement Enhances the Ancestral Antibacterial Function of a Bifunctional Scorpion Toxin.
Toxins
10:227.
Gao B, and Zhu S* (2018) Mesobuthus Venom-Derived Antimicrobial Peptides Possess Intrinsic Multifunctionality and Differential Potential as Drugs.
Front Microbiol
9:320.
Yuan S, Gao B, and Zhu S* (2017) Molecular dynamics simulation reveals specific interaction sites between scorpion toxins and Kv1.2 channel: implications for design of highly selective drugs.
Toxins
9:354.
Wang X, Gao B, Zhu S* (2016) Exon shuffling and origin of scorpion venom biodiversity.
Toxins
(Basel) 9:pii:E10.
Wu Y, Gao B, Zhu S* (2017) New fungal defensin-like peptides provide evidence for fold change of proteins in evolution.
Biosci Rep
37:pii: BSR20160438.
Zhu S*, Gao B (2017) Positive Selection in Cathelicidin Host Defense Peptides: Adaptation to Exogenous Pathogens or Endogenous Receptors?
Heredity
(Edinb). 118:453-465.
Zhang S
ζ
, Zhu L
ζ
, Yu J, Xu J, Gao B, Zhou C, Zhu S* (2016) Evaluating the potential of a loop-extended scorpion toxin-like peptide as a protein scaffold.
Protein Eng Des Sel
29:607-616. (ζ These authors contributed equally to this work)
Gao B, Zhu S* (2016) The drosomycin multigene family: three-disulfide variants from
Drosophila takahashii
possess antibacterial activity.
Sci Rep
6:32175.
Wu J, Gao B,
Zhu S*
(2016) Single-point mutation-mediated local amphipathic adjustment dramatically enhances antibacterial activity of a fungal defensin.
FASEB J
30, 2602–2614.
Zhu L, Peigneur S, Gao B, Zhang S, Tytgat J,
Zhu S*
(2016) Target-driven positive selection at hot spots of scorpion toxins uncovers their potential in design of insecticides.
Mol Biol Evol
33:1907–1920.
Zhang S, Gao B,
Zhu S*
(2015) Independent origins of scorpion toxins affecting potassium and sodium channels.
Evolution of Venomous Animals and Their Toxins
. DOI 10.1007/978-94-007-6727-0_12-1. Springer Science+Business Media Dordrecht.
Wang X, Umetsu Y, Gao B, Ohki S,
Zhu S*
(2015) Mesomartoxin, a new Kv1.2-selective scorpion toxin interacting with the channel selectivity filter.
Biochem Pharmacol
93:232-239.
Zhu S*
, Peigneur S, Gao B,Umetsu Y, Ohki S, Jan Tytgat (2014) Experimental conversion of a defensin into a neurotoxin: Implications for origin of toxic function.
Mol Biol Evol
31:546-559.
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